3/7/2023 0 Comments Low platelets high mpv15 Activated platelets secrete angiogenic growth factors, which contribute to tumor angiogenesis and thereby promote tumor formation. Platelets have been suggested to play an important role in the progression and metastasis of cancer. Several clinical studies have investigated the association between platelet counts and survival times in cancer patients. Further prospective studies with a larger number of patients in high-volume endocrine surgery centers are required to confirm our findings. We propose that MPV might be an important predictive factor for thyroid malignancies. MPV was significantly higher in patients with thyroid malignancies than in patients with benign thyroid diseases. Age, sex, hemoglobin level, WBC count, and platelet count did not significantly differ between the 2 groups. MPV was significantly higher in patients with malignant thyroid diseases than in those with benign thyroid diseases. Data on age, sex, MPV, white blood cell (WBC) count, hemoglobin level, and platelet count were collected retrospectively. This study involved 146 patients who underwent total thyroidectomy because of benign (99 patients) or malignant (47 patients) diseases of the thyroid. Therefore, in conditions that involve increased platelet activation, an increase in the proportion of young platelets and MPV is expected. Large platelets are relatively new, more reactive, and produce more thrombogenic factors. Platelets differ in terms of functional activity and size. MPV is a useful early indicator of platelet activation. This study aimed to determine the relationship between mean platelet volume (MPV) and thyroid malignancy by comparing patients who underwent surgery for benign or malignant thyroid diseases.
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